The Great Comedy Hustle for Muscle will see the likes of Lawrence Mooney, Judith Lucy, Lehmo, Hannah Gadsby, Bob Franklin, Anne Edmonds and Dave Thornton take to the stage together for a huge night of laughs.
Capping it off, Ben Salter and his band including members of Something for Kate and The Gin Club will even join in on the action for a special live set.
Funds raised will go towards FSHD muscular dystrophy research. FSHD is one of the most common forms of muscular dystrophy, a genetic muscle wasting condition affecting 1 in 7,500 people, both adults and children.